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Introduction: Dofetilide is a delayed rectifier potassium channel inhibitor used to treat patients with atrial fibrillation and flutter, and its use is associated with a risk of QT prolongation and ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the ...

Cisplatin appears to enter the cochlear cells through the organic cation transporter 2 (OCT2). There is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in ...

The objectives of this study were to evaluate the effect of sotorasib on metformin pharmacokinetics and pharmacodynamics and the effect of metformin on sotorasib pharmacokinetics in healthy subjects.

Quality of life (QoL) analysis in HPV positive oropharynx cancer (HPVOPC) patients in a randomized deintensification trial. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This ...

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Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. You may have access to this article through your institution.

Transporters other than OCT1, especially MATE1, have not been investigated regarding their role for imatinib accumulation in targeted cells for CML treatment yet. Here we investigate transporters that ...